本書從2003年開始在世界范圍內（主要是歐美）被用作課程教材，足以證明其影響力。這是第3版，在以前版本的基礎上進行了大幅修改。本書的核心理念在于：設計生物過程首先要基于對生物系統的模擬，因此，需要引入生物科學里數學、定量的方法，以期和工程科學完美結合，以指導最佳生物過程的設計，相對于國內大多數生物反應工程教材，本書更注重基礎、注重數學方法。這是特別值得借鑒的。
在基礎科學部分，本書設計第2、3、4、5章，分別從生物分子、物料守恒、生物反應熱力學和生化反應系統四方面介紹生物過程的科學實質、
第6、7、8章，結合前面四章內容，系統總結了酶、細胞、細胞群落三個生物反應過程。側重于用數學方法描述酶催化、細胞（群落）轉化過程，特別重視基礎科學和工程科學的結合。
第9、10、11章介紹生物反應中的工程問題，主要包括發(fā)酵過程的沒計、氣液傳質以及生物過程放大
本書理念先進，層次清楚，基礎和工程結合緊密，特別值得引入國內教育領域。
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《生物反應工程原理(原著第3版)(英文版)》是國外化學經典教材系列(影印版)。
1WhatIsThisBookAbout？
1.1NoteonNomenclature
2ChemicalsfromMetabolicPathways
2.1TheBioreflnery
2.1.1EthanolProduction
2.1.2ProducfionofP1atformChemicalsintheBiorefinery
2.2TheChemistryofMetabolicPathways
2.2.1TheCurrenciesOfGibbsFreeEnergyandofReducing
Power
2.2.2Glycolysis
2.2.3FermentativeMetabolism：OxidationofNADHinAnaerobic
Processes
2.2.4TheTCACycle：ProviderofBuildingBlocksand
NADH／FADH，
2.2.5ProductionofATPbv0xidativePhosphorylation
2.2.6ThePentosePhosphatePathway：AMultipurposeMetabolic
Network
2.2.7SummaryofthePrimaryMetabolismofGlucose
2.3ExamplesofIndustrialProduction0fChemicalsby
Bioprocesses
2.3.1AminoAcids
2.3.2Antibiotics
2.3.3SecretedProteins
2.4DesignofBiotechProcesses：CriteriaforCommercial
Success
2.4.1StrainDesignandSelection
2.4.2CriteriaforDesignandOptimizationofaFermentation
Process
2.4.3StrainImprovement
2.5T11eProspectsoftheBiorefmery
Problems
References
3ElementalandRedoxBalances
3.1TheContinuous.StirredTankReactor
3.1.1MassBalancesforallIdeal.SteadY-StateCorninuousTank
Reactor
3.2YieldCoefncients
3.3BlackBOXStoichiometries
3.4DegreeofReductionBalances
3.4.1ConsistencyTestofExperimentalData
3.4.2RedoxBalancesUsedintheDesignofBioremediation
Processes
3.5SystematicAnalysisofBlackBOXStoichiometries
3.6IdentificationofGrossMeasurementErrors
Problems
References
4ThermodynamicsOfBioreactions
4.1ChemicalEquilibriumandThermodynamicStateFunctions
4.1.1ChangesinFreeEnergyandEnthalpy
4.1.2FreeEnergyChangesinBioreactions
4.1.3Combustion：AChangeinReferenceState
4.2HeatofReaction
4.2.1NonequilibriumThermodynamics
4.2.2FreeEnergyReclaimedbyOxidationintheE1econTransfer
Chajn
4.2.3ProductionofATPMediatedbyF0一F1ATPSynthase
Problems
References
5BiochemicalReactionNetworks
5.1BasicConcepts
5.1.1MetabolicNetworkwithDivergingBranches
5.1.2AFormalMatrix.BasedDescriptionofMetabolic
Networks
5.2GrowthEnergetics
5.2.1ConsumptionofATPforCellularMaintenance
5.2.2EnergeticsofAnaerobicProcesses
5.2.3EnergeticsofAerobicProcesses
……
6EnzymeKineticsandMetabolicControlAnalysis
7GrowthKineticsofCellCultures
8PopulationBalanceEquations
9DesignofFermentationProcesses
10Gas-LiquidMassTransfer
11Scale-UpofBioprocesses
Index
Matrixalgebraisnecessarytounderstand,evenonasuperficiallevel,theconceptsdiscussedinpapersonSystemsBiology,andweintroducematrix-basedMetabolicFluxAnalysisinChap.5.Butthesubjectisintroducedslowlyaftersimplenetworkshavebeenstudiedbymethodsthatrequireverylittlebeyondbasicalgebra.Similarly,attheendofChap.3,methodsthatarenecessarytoevaluatethequalityofexperitnentaldataarediscussed,butonlyaftermanyexampleswhereelementalandredoxbalancesareusedtoanalyzesteady-stateratedataandtoderivethestoichiometryofbioreactions.WheninChap.6reactionscatalyzedbyimmobilizedenzymesaretreated,onemustapplysomebasicconceptsfromtransportphenomena.Diffusionintothepelletsistreatedwiththehelpofdetailedexamples.TheobjectiveistogivethereaderanunderstandingofthetopicwhichisontheparwiththatgiveninstandardtextsonChemicalReactionEngineering.Thebookhasmorethan100examplesandnotes.TheExampleswillhelpthereadertobetterunderstandthetextwhiletopicswhichextendthetext,sometimesbypointingtoapplicationsindifferentareas,aretreatedinNotes.TheteachingoftheexamplesisfurtherextendedintotheProblemsectionsofeachchapter.Someoftheexamplesandproblemsaresimpleillustrationsofthetext,whileothersaredetailedquantitativestudiesrelevantforbuildingupafurtherunderstandingofbio-reactions,bothforuseinscientificstudiesandfordesignofequipment.Thedesignexamplesoftenrefertothecollaborationoftheauthorswithmajorbio-techcompanies-suitablyreformulatedifnecessary.HopefullythesedesignexamplesdemonstratethatBio-reactionEngineering,bycombiningcoresubjectsfromChemicalEngineeringandtheBio-Sciences,contributestosecurebioprocessesaprominentplaceintheprocessindustry.
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